Increase dopamine receptors reddit. You want to build, create, and learn.

Increase dopamine receptors reddit I saw somewhere that the showers increase the d2 dopamine receptors in our… generally, when a receptor is bombarded by an agonist (the chemical that binds to the receptor and activates it), the neuron (or other cell in the body) may respond by downregulating the availabilty of the receptor, meaning that fewer receptors may be present on the cellular membrane to be bound to. latuda does the opposite. Users share their experiences and opinions on various methods to upregulate dopamine receptors, such as uridine, CDP-choline, forskolin, exercise, and gratitude journalling. This can result in long-term increase of self-confidence, motivation and focus. 9-me-bc is controversial, but has shown impressive effects on dopamine in animal studies. Hello everyone, In the episode about dopamine,Huberman says that you can raise your base line “wavepool” of dopamine by taking a cold shower. First I'd like to motivate this topic by the fact that dopamine receptors, have great impact upon people motivation/addiction behaviour and therefore many other things, like pointed out in this short review: Brain Dopamine Receptor Density Correlates with Social Status. Strangely however stimulating this receptor is also involved in anhedonia/blunting. compensatory effects. It works great for sleeping on stims though. going to bed after 1 AM is prolly the worst thing you can do for your mental health, mood and motivation. Ensuring NMDA hypo/hyper function isnt an issue, youll know if hypofunction is an issue if, for example, you take l-glutamine and react positively in terms of reward / motivation and feelings of euphoria. It has a long half life like 5 days so you were basically poisoning yourself. This, over time, will result in less stimulation from Bromantane, however there is also virtually no withdrawal. Ask your doc about a NSSRI such as wellbutrin. I use it as part of my stack and from a biochemical standpoint it should increase expression of the rate limiting enzymes (notably tyrosine hydroxylase) in the synthesis of dopamine, increase the rate at which those enzymes function, all while providing a supply of the precursor and epigenetically upregulating synthesis of dopamine receptors. Phenylpiracetam seems to increase the density of dopamine D2 and D3 receptors Dr. Natural routes to increase baseline levels of dopamine include: getting sufficient sleep, sunlight exposure and cold showers. Naltrexone isn’t a dopamine antagonist but it does antagonize dopamine indirectly. The receptor 5-HT2c is one that mediates the release of dopamine and adrenaline, generally as it becomes more active dopamine is lowered and adrenaline is released in higher amounts. This will cause a mild increase in dopamine but also increases the availability of dopamine receptors, so your body is more sensitive to circulating dopamine. Inositol - Increases dopamine D2 receptors in the striatum; Creatine - Increases dopaminergic neurotransmition by upregulating some NMDA receptors; p5p(active B6) - Increases dopamine synthesis and release; Melatonin(0,3mg) or absence of light while sleeping - Upregulates D2 receptors in the striatum. Very low doses increase dopamine release, probably because it's acting on the presynaptic kappa receptors. This allows the dopamine receptor to fire at full strength when adenosine is not bound to the heterodimer. They mainly revolve around avoiding dopamine spikes/stacking. You need to increase dopamine going in and how much of its substrate you have stockpiled alongside of receptor up regulation to create some real powerful dopamine changes. Regarding the dopamine, dopamine stays low in depression because you feel not motivated to do anything. If they want a general increase in working Dopamine, they have to ask for working DA, active DA, DA in the cleft and not "increase". Vitamin D3: A Role in Dopamine Circuit Regulation, Diet-Induced Obesity, and Drug Consumption; 20% and 50% increase in Dopamine receptor(1 and 2) gene transcription in nucleus accumbens Scientific Study There are many different dopamine receptor subtypes with vastly different effects & responses (some even oppose the action of dopamine), there are presynaptic & postsynaptic dopamine receptors, and there are different expressions of dopamine receptors depending on the region of the brain. Dopamine drives forward the evolution of our species. They later update that they have ADHD-PI and get diagnosed by a specialist. 9-me-bc has also shown to restore dead dopamine neurons. You might risk 1. This may be different for neuroatypical people with ADHD where dopamine sensitivity is high. Using seroquel etc to increase dopamine receptor density Protocol Query Leo Longevity did a video whereby he said low dosage seroquel nightly, titrated upwards in dosage over time, would increase dopamine sensitivity via upregulation of dopamine. Some report positive effects, others negative or no effects, and some ask questions or offer suggestions. On a supplemental level take l-tyrosine for dopamine and 5-htp for serotonin. L-Tyrosine won’t really help that much in the long term. alcar upregulates dopamine receptors. Made me super depressed and had zero energy from having no dopamine. of course this ca be felt after you move past 28 years old or so, the younger ones will recover faster but still will be affected. true. 5 mg, (usually at night). Which in response makes that person desensitized to the pleasure response over time. 'fasting can increase D2 receptors - BUT addiction is so much more than dopamine D2 receptors. "Ingest caffeine (approximately 100-400mg) in the form of coffee, tea or whatever form you prefer. I am not talking about a temporary increase of serum dopamine levels but rather something that would initiate the creation of greater synaptic connections in my dopamine d2 circuitry. Direct acting dopamine agonists like pramipexole or cabergoline or similar could work too. You want to build, create, and learn. I actually just posted two articles on this, the important thing to remember is there are different types of dopamine receptors, I don't have time to write up a big post here but the D2 receptor is one of the things Adderall works through, but long term or high usage can lead to death of the D2 receptors. Releasing agents do both. A natural stack to increase your dopamine baseline levels long-term: ALCAR(upregulates dopamine D1 receptor), Uridine Monophosphate(upregulates dopamine D2 receptor), Cordyceps (enhances the expression of the rate-limiting enzyme tyrosine-hydroxylase & also upregulates D2 receptor). However, there isn't evidence that it is possible to induce ST without an MAOI, so psilocybin by itself is probably not dangerous at all. The one people associate with mood is most likely one called 5HT-1a, though 5HT-2a is absolutely associated with mood in some ways, too. You can also get l-tyrosine from food. In situations where you have a high level of dopamine activity (say with regard to positive symptoms of schizophrenia) - the partial agonism, coupled with the higher affinity is a net reduction in dopamine activity In brief dopamine fast is 24 to 48 hrs (or more if possible) where you don't do anything besides eat (lean flavorless food with no sugar) drink water, walk, or journal thoughts for 1 to 3 days. It’s anti-serotonergic and pro-dopamine (and opioid) effects make it great against depression, anxiety, asthma , vascular constriction im equally if not more interested in receptors more than neurons. But do have a look through the pharmacokinetics and pharmacodynamics of some dopamine antagonists to see if one fits the bill. I take trazodone which lowers dopamine and saritonin. I'm not sure how long a time period this would take after discontinuing antipsychotics, but it's not instant. we know receptors can increase all over the brain. Increase a neurotransmitter and its receptors will get downregulated. Kratom downregulates dopamine receptors, but it doesn't deplete dopamine. I avoid caffeine after 2 p. Thanks. It's true that people with ADHD track lower dopamine on average, but it also rises when they are engaging with a hyperfixation. I wish people would stop trying to figure out ways to increase D2 receptors - its so much more complex than that. I would strongly recommend trying those before trying SAM-e. Essentially, it activates inhibitory neurons when they'd normally be dormant during high dopamine, which distributes downregulation. When you quit one drug you substitute it for another. So exogenous test can increase your dopamine levels and cause downregulation of Dopamine receptors, which would cause you some cognitive and confidence issues. Since dopamine receptors would still have to be in your body somewhere, increasing the number would increase the number of receptors in a fixed volume, therefore increasing the density. D2/3 receptor availability in the striatum and social status in human volunteers. ^ directly from Wikipedia. Vitamin D: vitamin D upregulates the dopamine d2 receptor. Serotonin is complicated in the brain (so is dopamine), there are a bunch of different types of receptor sites for serotonin in the brain that do wildly different things. A user on r/Supplements forum posts about their suspected low dopamine levels and asks for recommendations to raise them without tolerance. " Common misconception. Your dopamine receptors will reset and mundane things will interest you again. Most antipsychotics are dopamine antagonists, and as such they have found use in treating schizophrenia, bipolar disorder, and stimulant psychosis. nih. Amino acids are the building blocks of proteins, and 20 amino acids are needed to make all the proteins in your body. 58 Similarly, the indirect selective increase in the levels of dopamine in the frontal cortex and hippocampus is related not only to the effect on the 5-HT1B Less dopamine receptors: More dopamine spikes and drips Going far above and below the baseline dopamine levels Always feels the need for an addiction Stays happily for shorter periods How do you increase dopamine receptors?: Well, the common answer may not surprise you, which is dopamine detoxing. It will make sure your brain has the building blocks to create dopamine, but it won’t help “recover” dopamine receptors. The cause of the typically lower dopamine isn't a production issue, it's a matter of being understimulated by typical scenarios. The idea is that blocking opioid receptors for a period (around 4 hours) will over time cause your body to create more opioid receptors, which are crucially involved in mood and immunity/inflammation. I’ve done this and it’s worked great but… I was wondering what are some other ways you can increase your dopamine naturally ? I’m really struggling to focus these days even though I’m on It’s very complicated. After stopping antipsychotics, it will take a while for dopamine receptors to recover and start processing dopamine at normal levels again. Which means the same stimuli later will cause a greater effect. So it basically resets the reward center back to its normal state in addicts. Jan 9, 2025 · Good news is this is not permanent and you can increase the number of dopamine receptors to return to a normal baseline. Go get a third or even fourth opinion if you have to! As far as I know, using substances that increase dopamine levels could potentially lead to downregulation of dopamine receptors over time. Tianeptine and phenylpiracetam also increase dopamine receptor density but I wouldn't use them regularly. So it looks like the Tory government and our crumbling health service have comprehensively hung us out to dry. A sure-fire way to upregulate your dopamine receptors is to block them with a dopamine antagonist. because it indirectly increases dopamine and noradrenaline in the frontal cortex by partially stimulating the 5ht1a receptors. The synaptogenic aspects of psychostimulants (behavioral sensitization) delay tolerance but it still occurs due to D2 downregulation and ΔFosB-induced dopamine receptor desensitization. See full list on medicalnewstoday. receptor internalisation or 2. A reuptake inhibitor will keep the dopamine around for longer, leading to a higher overall level of dopamine as the brain continues to produce more. D2 receptors refresh quickly anyways. Don’t do this too close to sleep. My thought was if you lowered dopamine too much it would cause tinnitus. If you really want a very significant increase in dopaminergic activity then you need to take either stimulants, MAOIs or dopamine receptor agonists or a combination of these. As someone who tried LDN for 6 months it blows. Low stimulation causes the dopamine receptors to become more sensitive. blocking the 5ht7 receptors improves cognition and memory, and the stimulation of this same receptor is why you might feel sluggish and foggy on SSRI’s. Uridine + Omega 3 supposedly refresh D2 receptors quicker. Things that lower DeltaFosB are blackseed oil, butyrate, bromantane. This means that very low doses of stimulants can permanently increase the brain's sensitivity to dopamine (by increasing dopamine receptors in the high sensitivity state). As with all neurotransmitters there are different receptors that they have. It also lowers those neurotransmitters. wanting to increase Dopamine upregulation is hardly relevant if your brain is only going to release it in response to chemical stimuli. Treated animals displayed an increase in the dopamine receptor densities of 11% for those receiving 100 mg kg-1 and 18% for those receiving 500 mg kg-1 as compared to the control aged animals that had received no CDP-choline. Don't know if it repairs the receptors or restores healthy levels or what. -In addicts, they have a low amount of D2 receptors due to the amount of over-stimulation they expose themselves too. Also, it upregulates neurotrophins and by extension C-Fos, which enhances dopamine receptor sensitivity. This contradicts your own statement. for me personaly I have found it has been more helpful in the long run to try and upregulate my dopamine receptors than to take a dopamine precursor. It also focuses on lifestyle activities like exercise and nutrition for raising testosterone levels naturally or anything else related to testosterone the substance. We know that spiking dopamine - both acutely and chronically - from things like porn, gambling, junk food, drugs, etc. com Jan 17, 2025 · Here are the top 10 ways to increase dopamine levels naturally. This happens even in the case of an increase in Dopamine levels due to there not being enough receptors in the brain to receive it. Increasing dopamine D2 receptor expression in the adult nucleus accumbens enhances motivation. There are a few substances that upregulate dopamine. Thus, if you upregulate d2 receptors you will have less activation of the rewards pathways, for example. The enhancing effect on noradrenergic neurotransmission is related not only to a partial agonism of 5-HT1B but also to the stimulation of the 5-HT1A and the blocking of the 5-HT3 receptors. . Coffee for example increases dopamine but over time consistent use downregulates dopamine receptors slightly. Although most of them are excitatory, d2 autoreceptor activation reduces dopamine release. Which receptors depends on the individual drug's binding affinity, but most have high affinities for 5-HT2c. this may be a dumb question and a bit off topic but couldn’t this possibly be undesirable? Ive read that schizophrenia has a link with high dopamine, I obviously don’t understand the link but could this possibly bring about latent schizophrenia or raise the risk in some people? or is it the opposite and having better working receptors would mean your body uses it better and lowering the risk Vitamin B6 P5P form - Required for both serotonin and dopamine Zinc Picolinate - but be careful - you can take too much. Not to say you should do any of these. Notably, Tardive Dyskinesia patients have chronically upregulated dopamine receptors, but they're not abnormally euphoric or motivated. Also, you can also have low libido in depression. This happens because dopamine receptors in the nucleaus accumbens become downreugulated over time with repeated exposures to stimuli which provide a large increase in dopamine signalling. In essence DA's imitate the actions of dopamine when levels are low - thereby are less directly or overtly dopaminergic, but rather more subject to natural downstream activity from HPMA. When people talk about how social media is bad and has negative effects on dopamine, why is that? Social media can cause transient spikes in dopamine. For depression and anti-inflammation its used in really low doses, around 4. exercise has been well documented to increase dopamine receptors. I just wanted to ask. I’ve been listening lately to Huberman and I’ve developed the following protocols to increase my baseline dopamine. PHC normalized CUMS‑induced disorders of dihydroxyphenylacetic acid, dopamine, 5‑hydroxytryptamine (5‑HT) and 5‑hydroxyindoleacetic acid in serum and/or hypothalamus of depression‑like rats. Downregulation basically means the receptors become less responsive to dopamine in order to adapt to the presence of more dopamine than usual. Pavlovian 15 votes, 26 comments. the higher the spike, the lower the fall. On a personal psychological note you should get into eastern philosophy particularly Buddhism. Testosterone and Dopamine have a two-way relationship. NEW ZELAND DATA SHEET ESCITALOPRAM: "Escitalopram has no or very low affinity for a series of receptors including 5-HT1A, 5-HT2, DA D1 and DA D2 receptors, α1-, α2-, β- adrenoceptors, histamine H1, muscarine cholinergic, benzodiazepine, and opioid receptors. Plenty of drugs that increase d2/d3 signaling will decrease d2/d3 receptor expression via desensitization or other mechanisms. gov/11978191/ The problem is, when you stop doing that dopamine-releasing behavior, your synapses are used to having more dopamine in the synapse and lack enough receptors to accept the dopamine you create normally. These support the metabolic pathways for serotonin and catcecholamine synthesis (dopamine, noradrenalin, etc) The simplest answer is that dopamine doesn't "make you happy" in any straightforward sense. Dopamine D2 Receptor: Uridine, CDP-Choline, Inositol, Dopamine D1 Receptor: Alcar Dopamine D1 & D2 Receptor: Forskolin, Sulbutiamine Get the Reddit app Scan this QR code to download the app now may be related to an upregulation of striatal D2‐dopamine receptors. I'd look into it if I was you . Your second doc is a joke. ncbi. 5-HT1A partial agonism promotes a dopamine response similar to other adjuvants as Mirtazapine and Aripriprazole, the anticholinergic effects are also supressing acetylcholine from binding to cholinergic receptors and indeed reestablish dopamine/ACh balance when dopamine is blocked which is why doctors use anticholinergics like Benzatropine to And normally, these receptors' activation prevent excessive dopamine levels by downregulating the firing rates of dopamine-producing neurons. the same situation may happen in times of A point: there are many different types of dopamine receptors. MC4 receptor stimulates libido and erections, like PT-141. Might help. I can relate to you minus the alcohol binge. Meh increasing receptors is nice but that’s like adding more offices for the same amount of workers. The main goal in recognizing whether something you’re about to do or take, will increase your dopamine baseline or decrease your dopamine. Clozapine may be an exception. Nortriptyline and mirtazapine can help increase dopamine by blocking the 5HT2C receptor, and nortriptyline couldn't just be helping with dopamine but in other ways too. Which is weird because people who take Buspar, whre it raises your dopamine levels get spikes from that. A dopamine agonist binds to specific dopamine receptors and stimulates these receptors to release more dopamine. , with rare exceptions. I also took Latuda a few weeks back and maybe had spike from it. UV exposure, midday sun, is the best thing for c-fos. Because caffeine is a receptor antagonist for adenosine receptors, it doesnt activate the receptor but still blocks adenosine from binding. Amphetamine doesn't raise his dopamine levels on a long term - quite the contrary since he'd get higher dopamine receptor density. It appears NAC has different effects from a low dose vs very high dose, according to Examine: . By letting go of attachments you are exiting the hamster wheel of dopamine. In terms of 'power' it is DRA>DRI>DA. Not having enough dopamine makes tasks feel less rewarding and harder to do, leading to dopamine seeking behavior, trouble with concentration and self control, etc. “more dopamine” is not always a good thing. Lack of motivation is caused by depression and low libido are mostly side effects of antidepressants. If he had higher dopamine receptor density, then it follows 'dopamine levels' are also elevated. Certain drugs that increase dopamine release/block reuptake have rewarding, euphoriant effects, but endogenous dopaminergic signalling is complicated and can't really be reduced to a signal emotional state. So when salvia lowers kappa opioid receptors, it causes dopamine striatal levels to lower while upregulating dopamine receptors. You could have induce an extremely high increase in dopamine in the brain but it won't matter if nearly all your dopamine receptors are blocked by an antipsychotic. High dopamine is the opposite. That’s the short term ^ ALCAR, which improves ATP/ADP ratio through contributing to fatty acid oxidation, and is also known to have an anti-inflammatory & antioxidant effect, reverses the Dopamine D1 receptor-type downregulation seen with chronic cocaine (Thr34 phosphorylation which is pro-reward gets downregulated and this is reversed by ALCAR). Jul 10, 2020 · Tianeptine doesn’t appear to act on any receptor (except the μ-opioid receptor), but it does increase dopamine release and enhances the functional responsiveness of dopamine D2 and D3 receptors . There's some evidence of some dopamine agonists like pramipexole to restore the dopaminergic system too but it's pretty risky due to potential DAWS. The reason of ‘dopamine frying’ is DeltaFosB accumulation and subsequent c-fos downregulation. So when you take benzodiazepines, they activate GABA receptors, which reduces the production of dopamine. Think it because it increased the dopamine too much, other reviews on Amazon people were mentioning the same thing. One amino May 24, 2024 · Learn how to upregulate dopamine receptors with supplements, lifestyle changes, and meditation. No, I don't think so. It seems that you should only take it a couple of times a week at low dosages "whereas aging has been associated with reduced dopamine receptor and transporter binding, it has also been shown to be accompanied by upregulation of (dorsal) striatal dopamine synthesis capacity. L-Tyrosine is a supplement that can increase dopamine. But, in my opinions there are other ways. Baseline is based on whether you had to go through resistance/struggle to experience that reward. Hashtag homeostasis or something idk And then it takes time to wean yourself from the substance with withdrawal effects worse than what you originally took it for It's structurally a serotonin analogue, which binds primarily to 5-HT2A receptors, which are implicated in serotonin syndrome (excitotoxicity due to overstimulation). You want dopamine, and you want it in abundance. D3 receptors might be more relevant to pleasure and motivation than D2 receptors if I'm not mistakenRexulti also is a partial dopamine agonist and I think vraylar>rexulti>ablify in terms of Tolerance and withdrawal, in regards to stimulants, involves the reduction of dopamine receptor sensitivity, as well as the reduction of dopamine. This makes sense because high amounts of dopamine are linked with increased anxiety. leads to the desensitization and downregulation (decrease in sensitivity and number) of dopamine receptors, especially in the context of extreme, artificial stimuli, and especially with things that persistently increase That said, if you want to sensitise a receptor subgroup taking a competitive reversible antagonist would probably achieve 'sensitisation'. This post explains the neuroscience of addiction and dopamine, and provides 10 ways to boost dopamine naturally. So meditation helps accomplish this in two ways. https://pubmed. Desire (dopamine) is the root of all suffering. I think it's because nicotine actually upregulates nicotinic receptors in the mmesolimbic dopamine system, making you more sensitive to acetylcholine in the temporary absence of nicotine. does it also increase serotonin receptors? This subreddit is for questions and discussion related to testosterone replacement therapy and testosterone. There is a strong difference between increasing DA levels full stop, increasing release and increasing working DA. Nicotine is pretty unique in upregulating its receptors after chronic use while most drugs down regulate their relevant receptors. That's why Im looking for this. Antipsychotics downregulate the number of dopamine receptors in the brain. BPC 157 has a "modulatory effect" on dopamine system. This upregulation of synthesis capacity has been related to, if anything, worse rather than better neurocognitive functioning relative to young adults. Which starts to reset the brain receptors for the next few hours. Assuming we're facing weeks, maybe even months without proper access to medication, I guess it's time to dust off a few of those old coping strategies. Abilify primarily hits D2 receptors (it also affects d3 but to a much lesser degree than vraylar, another partial dopamine agonist antipsychotic). An increase of one, causes increase of the other. Magnesium Glycinate - 400-600mg / day split over day. Giving you an actual break of mental stimulation and emotional anxiety. So, I’m wondering if there’s anything I can take to increase the sensitivity of my dopamine receptors (upregulate them) or just help in general based on what I've said because I'm not sure what's exactly I actually think the reason sexual sides are counteracted when they are is not even because of the dopamine but because of the melanocortin effect at MC4. This would fix my issue. How to use this info to your advantage. However, upon those advantages above I think that there are more important The mr happy stack is known to increase dopamine receptor density particularly in areas of low density, not sure how the genetic predisposition will affect this, could wind up making it more or less effective for you, but either way it should do something. also sleeping very early like before midnight and consistently will improve mood, mindset, overall personal 'energy' a lot. Yeah you have more potential but your output will remain mainly the same. I've used it on and off for years now. Vesicular dopamine release from neurons appears to be enhanced in the presence of N-acetylcysteine at low concentrations yet very high concentrations (10mM) tend to inhibit release which may be related to how glutathione can increase glutamate evoked dopamine release. But remember dopamine doesn't determine the hedonic experience, so moderate doses can be really positive despite dopamine suppression, dependent on set and setting. That specifically targets the dopamine receptors to help boost dopamine. Martinez and colleagues found that increased social status and increased social support correlated with the density of dopamine D2/D3 receptors in the striatum, a region of the brain that plays a central role in reward and motivation, where dopamine plays a critical role in both of these behavioral processes. ADHD meds don't increase the production of dopamine, they are a concentrated stimulant. m. Abilify is a partial agonist of dopamine receptors that has a higher affinity to D2 receptors than even endogenous dopamine. You could have a billion dopamine receptors and soo much dopamine but you need to train your brain to release it at whatever time you may feel it is the most important. Spikes in dopamine are always followed by drops in dopamine. It is possible however for caffeine to increase dopamine signaling and still increase d2/d3 receptors the striatum, but the mechanism that potentially does it is what I’m curious about. It's the 5-HT2a antagonism that makes atypicals stand out: said to increase cortical dopamine, which is theoretically deficient in those with a psychotic disorder, whereas there is too much dopamine in the limbic area, where D2-type and D2-like receptors are, and atpyicals block D2/D2-like receptors in this area. some of the things that have helped me with this are sulbutiathiamine, uridine monophosphate, citocoline, NAC and cordyceps. Try Hey guys. There's a difference between receptor downregulation and neurotransmitter depletion. People recover from addictions while still using other drugs, smoking and eating like crap. It’s kinda like if you have a room with 5 people in, then you suddenly add an extra ten. Therefore making it a "super receptor". Moreover, PHC enhanced the expression of tyrosine hydroxylase and reduced the levels of dopamine D2 receptor and 5‑HT2A receptor in hypothalamus. Then as the dose increases it suppresses dopamine more and more. However, that's the exact mechanism of action that causes the movement disorder Tardive Dyskinesia. nlm. Today was my first cold shower. In this short podcast clip, he explains how much the following substances increase dopamine above baseline levels: Chocolate: 150% Sex: 200% Nicotine: 250% Amphetamine: 1000% Why does this matter? Well, for every dopamine spike, there's an equal and opposite crash (hence, the "Adderall comedown"). The brain is able to produce dopamine very quickly, and the only way to actually deplete dopamine levels is to take dopamine releasers regularly. Posted by u/Glum_Interaction_160 - 1 vote and 7 comments A dopamine antagonist, also known as an anti-dopaminergic and a dopamine receptor antagonist, is a type of drug which blocks dopamine receptors by receptor antagonism. I think my dopamine binge was probably video games and other things. I suffer from PAWS, which is caused by severe dopamine D2 receptor disregulation. npohw acbn qtygw ivbp aonkpn ykjndfm wvdf ujfsz wupx ohag hkq lgcv xouie hjwst bfmeji