Clomipramine cat It is also Clomipramine For Dogs and Cats: Uses, Side Effects and Dose Calculator Based on Weight, Dose (mg/kg) and Concentration. 1 mL, 9 mL, 2 Clicks=0. amitriptyline), animals with a history of seizures, liver disease, kidney disease, heart problems, asthma, diabetes, high blood Cats: While less commonly used in cats, clomipramine may be prescribed for certain behavioral conditions, such as urine spraying. Four cats became lethargic at higher doses, but this resolved when the clomipramine dose was reduced. Contents of the pack and other information. Over 28,000 peer-reviewed resources: Canis, Bovis, Equis, Lapis & Exotis. Clomipramine (Anafranil ®) has been tested on 26 cats at the dosage of 5 mg once a day. gatsby-image-wrapper [data-placeholder-image]{opacity:0!important}</style> Please refer to the full label for dosing information and all risks associated with Clomipramine Hydrochloride tablets. You can select a medicine from this list to find out CLOMICALM ® (clomipramine hydrochloride): For use in dogs only. Buy high-quality N-Nitroso Desmethyl Clomipramine from SynZeal. It increases the amount of serotonin that needs to maintain There is a solitary report of suspected antidepressant-induced UR in a feline patient. Many pets have anxiety about separation from their owner, aggressive pets with whom they share their home, and other In the cat, overgrooming, licking, biting, chewing, and compulsively pulling out hair can lead to hair loss, thin, uneven coats, or baldness. Being able to compound this Welcome to Omni's cat Benadryl dosage calculator, a simple tool to determine what dose of Benadryl is safe for your cat. Twenty-five cats were Clomipramine was effective in controlling the signs of anxiety-related and obsessive-compulsive disorders in 10 of 10 assessable cases when used in combination with behaviour modification. 804. What Clomipramine is and Tricyclic antidepressants (TCAs) include the medicines amitriptyline, clomipramine, dosulepin (Thaden®), doxepin (Xepin®), imipramine, lofepramine, nortriptyline and trimipramine. 1. You can find detailed information about this drug in the official Patient Information Leaflet (PIL). This behavior typically has a medical The objectives of this in vitro study were to describe cytochrome-dependent metabolism of clomipramine in canine and feline microsomes, compare metabolic profiles between cats, rats Clomipramine Clomicalm 5mg Tablets For Dogs and Cats 30. It's the generic name for Some cats may show an increase in affectionate behavior; big, dark, round (dilated) pupils. Name Review Subject Required. Depression: the exact cause of Clomipramine has the International Union of Pure and Applied Chemistry (IUPAC) name 3-chloro-5-[3-(dimethylamino)propyl]-10,11-dihydro-5H-dibenz[b,f]azepine Objective: To determine the optimal dosage of clomipramine for the treatment of urine spraying in cats. Clomipramine is used in dogs to treat behavior problems such as separation anxiety, excessive barking and destructive behavior. Clomipramine inhibits the removal of serotonin in the brain so that the serotonin present is present for a longer time. ARK2009. Clomipramine may also be useful in cats, but cats tend to be more Inappropriate elimination or behavioral periuria/perichezia is likely the most reported feline behavioral problem worldwide. Cat Care Forums. Animals: 67 Clomipramine. The only other medication which has shown to be consistently effective in OCD is the serotoninergic tricyclic Clomipramine hydrochloride. Selective serotonin reuptake inhibitors. 25, 2. This medication may be used to treat obsessive issues (such as tail Clomipramine (Anafranil), FDA approved for human use, is also used in veterinary medicine to treat aggression and obsessive-compulsive disorders such as tail chasing. 93]): (Table 6 1. Clomipramine is the most specific for serotonin of all the tricyclic antidepressants but differs Clomipramine, also known by the brand names of Clomicalm® and Anafranil®, is approved for the treatment of canine behavioral disorders classified as separation anxiety. Aleo M, Ross S, Becksei C et al. 5 The average maintenance Once your cat’s behavior is stable, they can be gradually weaned off the medication. The average maintenance dosage was 0. References: 1. Journal of the American Animal Hospital Association 41(1): 3-11. In children, accidental ingestion should be regarded as serious. It may be used initially or may be considered if a Continue to take clomipramine even if you feel well. It is used to treat depression and obsessive-compulsive disorders (OCD). APO-Clomipramine belongs to a group of medicines called tricyclic antidepressants. v69i1. Clomipramine can also be used in cats to A 10-year-old, female, spayed shorthair with presumed psychogenic alopecia was treated with clomipramine (1 mg/kg body weight/day). In cats, clomipramine may be used to prevent urine Based on the findings of Mertens et al. 3. 1-mL at Chewy. Cats that have previously been timid in the face of repeated attacks may turn on their attacker. Drugs used for problem behaviors are not approved for use in cats, except for clomipramine, which is licensed in Australia for cats that are urine spraying; 21 A cat that habituates to one type of sound does not, as a consequence of this habituation, become habituated to other sounds. 25-5kg. The medicines below all contain the following active ingredient(s): clomipramine. Following a medical workup, a 4-week clomipramine trial was instituted, using The objectives of this in vitro study were to describe cytochrome-dependent metabolism of clomipramine in canine and feline microsomes, compare metabolic profiles 1. CAS No. Patients sensitive There was a significant (P<0. Clomipramine (Clomicalm®, More in cats compared to dogs, cetirizine appears to help with atopic dermatitis, also known as allergic skin disease. 75-10. Results are highly significant: clomipramine is responsible for a reduction of urine Product Name: Clomipramine: Cat. Drugs. In cats, research has shown clomipramine to reduce urine spraying by 90%. 1 Inappropriate urination of all types—toileting behavior as well as marking—is In this Audio Summary, Anne-Claude asks, in cats with psychogenic alopecia, is overgrooming reduced by the use of clomipramine compared to untreated cats? Read the full Fluoxetine, Paroxetine, Sertraline, Clomipramine ; Buspirone. Possible side effects. This medication is FDA-approved to treat Clomav 20mg - 120 Tablets (Clomipramine) To aid in the treatment of anxiety disorders such as destructiveness, excessive vocalisation, loss of toilet control, associated with separation Quantity: Decrease Quantity: Increase Quantity: To determine whether clomipramine differs from fluoxetine in reducing feline urine marking; whether reduction of marking continues in cats treated >8 weeks; whether recurrence of marking, after Dogs: Should be administered twice daily at a dose rate of 1–2 mg clomipramine hydrochloride/kg body weight to give a total daily dose of 2–4 mg/kg. 3 Medscape - Indication-specific dosing for Anafranil (clomipramine), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation Abstract Objective—To determine whether clomipramine differs from fluoxetine in reducing feline urine marking; whether reduction of marking continues in cats treated > 8 Twenty-five cats exhibiting at least four episodes of vertical urine marking per week were assessed. Neilson, J. Design—Randomized controlled multicenter clinical trial. The nature of the occurrence of bronchopneumonia in children is explained by the presence of lung tissue, which is not fully . View Clomipramine’s uses, side Cats with a high baseline level of anxiety – which may present as inter-cat aggression, urine marking, separation anxiety, self-mutilation, or generalized fear – are candidates Clomipramine hydrochloride has been used in dogs at 1–3 mg/kg to reduce lick behavior for canine lick granuloma and for stereotypies such as circling and tail chasing, and in cats at 0. cat meds. APO-CLOMIPRAMINE Clomipramine Hydrochloride Tablets 10 mg, 25 mg and 50 mg clomipramine hydrochloride Antidepressant / Antiobsessional APOTEX INC. 0001) decrease in urine spraying when the cats were on clomipramine, with 20 of 25 cats having a ≥75% reduction in spraying within 4 weeks. Supelco. gatsby-image-wrapper noscript [data-main-image]{opacity:1!important}. Following a medical workup, a 4-week clomipramine trial was instituted, using a When it was evident that the effectiveness of clomipramine in cats treated for 8 and 16 weeks was no greater than that of flu-oxetine, the trial involved primarily cats treated with fluoxetine with a In a study of the pharmacokinetics of clomipramine in six adult spayed cats, the mean half‐life of clomipramine after administration of a single IV dose of 0. 5. If the cat does not perform the behavior, then the reduce excessive grooming in cats9. 85 Target: Serotonin Transporter Pathway: Neuronal Signaling Clomipramine and its major metabolite. 5 mg/kg PO q 24 hours) (n = 12). Habituation is not the same as failing to respond to Hello fellow cat lovers. How to take Clomipramine. Following <style>. 1998 Mar;69(1):22. Clomipramine transdermal gel compounded for dogs and cats Buy Clomipramine CAS No- 303-49-1, a high quality product from Simson Pharma Limited, a Leading Manufacturer and Exporter of Clomipramine accompanied by Certificate of Analysis. α 1-receptor blockage and β-down Clomipramine Hydrochloride 75 mg (0632 75mg) View larger images. Side Medication: Clomipramine Your cat has been prescribed Clomipramine for the treatment of a behavioral problem. I took it for 2 years without significant side effects except anorgasmia. Recent references from PubMed and VetMedResource. , C 19 H 23 ClN 2 HCl MW = 351. ; Clomipramine is used in the treatment of Depression, Anxiety, Bed-wetting, Obsessive-compulsive disorder, Insomnia, Neuropathic pain. Tricyclic Antidepressant compounded for dogs and cats. They Feline housesoiling still represents the most common reason cat owners seek behavioral advice from their veterinarian. 5-mg/0. com Mobile App. Chemicea Pharma is one of the leading manufacturer and exporter of Clomipramine impurities. This medication is FDA-approved to treat Clomipramine is a tricyclic antidepressant used in dogs and cats for obsessive-compulsive disorders, as well as other behavior disorders. Protect from moisture. 5 to 1 mg/kg [0. OCD is a nervous condition wherein a person has recurring thoughts or ideas or does repetitive things Clomipramine is a tricyclic antidepressant (TCA) that primarily exerts therapeutic effects through potent serotonin reuptake inhibition. 9 lbs 30 ct and other Generics from top brands at 1800PetMeds and save. After 2 years of use I developed a strong erectile Description for Anafranil. The response in one Clomipramine is used to treat obsessive-compulsive disorder (OCD). 5 mg/kg daily for a minimum of 30 days, 20 of 25 cats had ≥75% reduction in Product Name: Clomipramine: Cat. Some cats benefit from staying on anti-anxiety medications for six to 12 months—or longer. I am told this drug takes about 3 weeks to Buy Clomipramine CAS No- 303-49-1, a high quality product from Simson Pharma Limited, a Leading Manufacturer and Exporter of Clomipramine accompanied by Certificate of Analysis. com. Cats: Should be administered once daily at a dose rate of 0. Anxiety is not a problem exclusive to humans. Placebo and Examples of TCAs include amitriptyline, clomipramine, dosulepin, imipramine, lofepramine and nortriptyline. Clomipramine is a tricyclic antidepressant that may be useful in cats, especially when inappropriate urination is involved. : HY-B0457A CAS No. CP-C30003: Psychogenic alopecia in a cat: response to clomipramine. 5 May cause urinary retention in cats. An aid in the treatment of urine spraying in desexed and female cats 3kg or more Cats may become irritable and anxious, or experience increased aggression toward people or other animals in their environment. The time to peak plasma concentration of clomipramine in cats was longer than in humans (Tmax of 3 h) (Evans et al. 5 years ago, she has been In a study in which 25 urine marking cats were treated with clomipramine at a dose of approximately . How to store Clomipramine. It My vet recommended Clomicalm or Clomipramine to help treat my cat’s urine spraying. 45 mg/lb], PO, q 24 h). Cats were assigned alternatively to either a group receiving placebo (n = 13) or a group receiving clomipramine hydrochloride (0. This medication is FDA-approved to treat obsessive Clomipramine is a tricyclic antidepressant (TCA) that primarily exerts therapeutic effects through potent serotonin reuptake inhibition. 6. From the known mechanism of action. 001) association between clomipramine use and the number of cats that cease or reduce urine spraying by at least 90% (OR 4. 31. Clomipramine, like other TCAs, undergoes Buy Clomipramine HCl Compounded Transdermal for Cats, 2. To diagnose FHS, other conditions related to the skin and nervous system The objectives of this in vitro study were to describe cytochrome-dependent metabolism of clomipramine in canine and feline microsomes, compare metabolic profiles For the treatment of sterotypic behaviours and aid in the treatment of anxiety disorders, in dogs of 1. Storage. 4102/jsava. Comments Required. Number: E4907: Manufacturer/Supplier: Selleck Chemicals 14408 W Sylvanfield Drive, Houston, TX 77014 USA Toll Free:(877) 796-6397 A 10-year-old, female, spayed shorthair with presumed psychogenic alopecia was treated with clomipramine (1 mg/kg body weight/day). FREE shipping and the BEST customer service! WE have a 9yr old cat who several years ago developed OCD so badly that Objectives: To determine whether clomipramine differs from fluoxetine in reducing feline urine marking; whether reduction of marking continues in cats treated >8 weeks; Serotonin, in simple terms, is associated with the cozy, happy feelings of comfort. Rating Required. Clomipramine. The cat developed urinary retention within 2 days. Cat Behavior Clomipramine. Do not administer to dogs with There was a statistically significant (P<0. The safety margin is quite low with toxic side effects observed at 2–3 mg/kg, although fatal does is >10 times the recommended dose. Recently, clomipramine proved useful in the treatment of a case of psychogenic alopecia. Following a medical workup, a 4-week clomipramine trial was instituted, using a Twenty-five cats exhibiting at least four episodes of vertical urine marking per week were assessed. $53. SAFC. Store below 30°C (room temperature). 5, or A 10-year-old, female, spayed shorthair with presumed psychogenic alopecia was treated with clomipramine (1 mg/kg body weight/day) and developed urinary retention within 2 Clomipramine was effective in controlling the signs of anxiety-related and obsessive-compulsive disorders in 10 of 11 cats and was well tolerated. 2004. Quick View. 3–1. No. If your cat has been displaying symptoms of an allergic reaction, motion sickness, or vomiting 😿 and Clomipramine (brand names: Clomicalm®, Anafranil®, Clofranil®, Clopram®, Clopress®, Equinorm®, Hydiphen®, Maronil®, Novo-Clopramine®, Placil®, Tranquax®, Zoiral®) is a tricyclic antidepressant medication used to treat Clomipramine belongs to a group of medicines called tricyclic antidepressants. Some types of TCAs, such as amitriptyline, can also be used to treat chronic Clomipramine is a tricyclic antidepressant (TCA) that primarily exerts therapeutic effects through potent serotonin reuptake inhibition. : 303-49-1 Molecular Formula: C₁₉H₂₃ClN₂ Molecular Weight: 314. A change in behavior is often one of the early signs of physical disease and in addition can aggravate Effects of clomipramine on cats presented for urine marking. It is freely soluble in water, and in methylene chloride, soluble in alcohol. This review focuses on pre-appointment medications used to decrease fear and anxiety in dogs and cats related to veterinary visits. These cats should get a yearly examination, Findings in a series of cats with severe FIC showed that the clinical signs of some cats were reduced during amitriptyline treatment during a 12- month period. This includes information on what the medication is for, how to take it, possible side Clomipramine is a weight based medication which means some pets may require a lower or higher dose than those commercially available. Clomicalm (also known as Anafranil) is the brand name of clomipramine (klo-mi-pra-meen) a tricyclic antidepressant manufactured by Novartisthat is used to treat several behavioural disorders in cats, dogs, birds and humans. Clomipramine, also known by the brand names of Clomicalm® and Anafranil®, is approved for the treatment of Publications Refereed papers. JAAHA 37 (4), 313-318. 6 In this report, the cat had been receiving clomipramine for suspected psychogenic alopecia and subsequently presented for stranguria. Manufacturer. In clinical use, clomipramine is recommended at the dosage of 0 Twenty-five cats exhibiting at least four episodes of vertical urine marking per week were assessed. It helps decrease persistent/unwanted thoughts (obsessions), and it helps reduce the urge to perform repeated There was a statistically significant (P<0. Anxiety, aggression, compulsive disorders, urine marking. He said it is an anti depressant? Will it help? Surely my cat can’t be depressed? Do animals even get depressed? WHAT IS CLOMICALM Clomipramine is in the class of drugs called tricyclic antidepressants that are commonly used in veterinary medicine to treat behavioral disorders in dogs and cats. Abstract Objective—To determine the optimal dosage of clomipramine for the treatment of urine spraying in cats. 0001) decrease in urine spraying when the cats were on clomipramine, with 20 of 25 cats having a > or =75% reduction in spraying within Although urine spraying is typical in sexually intact cats, approximately 10% of neutered males and 5% of ovariohysterectomized females urine spray. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. This can be If the cat performs the behavior when cued, then the cat receives something pleasant, such as a food treat, play with a toy, or petting. It helps ease the symptoms of a number of different conditions. Its efficacy is unique among tricyclic antidepressants and may be related to its relatively high The objectives of this in vitro study were to describe cytochrome-dependent metabolism of clomipramine in canine and feline microsomes, compare metabolic profiles Clomipramine was first discovered in 1964 by the Swiss drug manufacturer Ciba-Geigyr and was the first drug that was investigated for and found to be effective in the treatment of OCD. HOW THIS Apo-Clomipramine: Clomipramine belongs to the class of medications known as tricyclic antidepressants. Occasionally some cats missed one dose of clomipramine; this was followed sometimes by recurrence of spraying or grooming behaviour within 1 to 2 days. USP. Fluoxetine. Clomipramine and fluoxetine were equivalent in treating urine marking and most cats return to marking after abrupt drug withdrawal, and a second course of treatment can be There was a statistically significant decrease in urine spraying when the cats were on clomipramine, with 20 of 25 cats having a > or =75% reduction in spraying within 4 weeks. The effectiveness of clomipramine in the treatment of Chlorpheniramine for cats is an antihistamine medicine that veterinarians primarily prescribe to help alleviate the symptoms of a range of allergies. Free shipping on orders over $49! Twenty-five cats exhibiting at least four episodes of vertical urine marking per week were assessed. Cats in the 3 treatment groups were given tablets con-taining 0. Anafranil ™ (clomipramine hydrochloride) Capsules USP is an antiobsessional drug that belongs to the class (dibenzazepine) of pharmacologic agents clomipramine. APO View Medication: Clomipramine & more Felis resources at Vetlexicon. Clomipramine brand names. Although widely used in veterinary medicine, Clomicalm has not been approved by the See more Your veterinarian has prescribed clomipramine to treat a behavioral problem. SSRIs are associated with many adverse effects but are usually well tolerated. Inappropriate elimination can be seen in all ages and beginning of content Active ingredient: clomipramine. C-118. The cat developed urinary retention Cats that are allergic to Clomipramine or other tricyclic antidepressants (ex. A little less than 50% of cats may see a response where their Abstract. Clomipramine is FDA approved for use in dogs, but is used"off-label" in Urine Spraying and Marking in Cats: Though less commonly, clomipramine may be used to address inappropriate urination behaviors in cats, such as urine spraying or Clomipramine is used to treat obsessive compulsive disorder (OCD). In dogs, it is used to treat obsessive-compulsive behavior, separation anxiety or dominance aggression. TCAs are structurally similar to phenothiazines. Keep out of reach of children. Design: Randomized controlled multicenter clinical trial. Thinking outside the box: feline elimination. Following a medical workup, a 4-week clomipramine trial was instituted, using In a recent study, clomipramine was effective in controlling signs of anxiety-related and obsessive-compulsive disorders in 10 of 11 cats and was well-tolerated. , 2006). 99 Helped my cat when she was having all sorts of issues with skin issues and A cross-over study was performed in six adult spayed cats to determine the pharmacokinetics of clomipramine and its metabolite, desmethylclomipramine (DCMP) after Clomipramine, Prescribing information, Obsessive-compulsive disorder, CKS. If you suddenly stop taking clomipramine, you may experience Overview of Clomipramine (Clomicalm®) for Dogs and Cats. NA, Synonyms: , Chemical name: N-(3-(3-Chloro-10,11-dihydro Tricyclic antidepressants are well absorbed from oral administration with a bioavailability of 90% in cats (Lainesse et al. 23, 95% CI [2. 00–8. 150 Signet Drive Symptoms of clomipramine pills appear after a three-day inpatient treatment or three days after discharge. Why has my cat been prescribed A double-blind, placebo-controlled clinical trial was conducted to determine the efficacy of clomipramine hydrochloride in cats with psychogenic alopecia. I was wondering if anyone in here has had their cat(s) on clomicalm? We have an adult female cat that, since we moved to our new house 4. Access drug & treatment information, identify pills, check interactions and set up Clomipramine, the 3-chloro analog of imipramine, is a dibenzazepine-derivative tricyclic antidepressant (). tricyclic antidepressants that are commonly used in veterinary medicine to treat Clomipramine is a strong, but not completely selective serotonin reuptake inhibitor (SRI), as the active main metabolite desmethyclomipramine acts preferably as an inhibitor of noradrenaline reuptake. Thread The Clomipramine is Results are highly significant: clomipramine is responsible for a reduction of urine spraying (of more than 75%) in 80% of the cats. 23 to 0. Clomipramine hydrochloride solution. Number: E4907: Manufacturer/Supplier: Selleck Chemicals 14408 W Sylvanfield Drive, Houston, TX 77014 USA Toll Free:(877) 796-6397 Clomipramine(Anafranil) generic is a tricyclic antidepressant (TCA), prescribed for obsessive-compulsive disorder. Precautions. Palatability Testing of Oral Chewables in Veterinary Medicine for Dogs. ; Landsberg G M (2001) Clomipramine - beyond separation anxiety. Key drug interactions with clomipramine include: MAOIs — do not give clomipramine for at least 3 Clomipramine Cat. Do not stop taking clomipramine without talking to your doctor. An 8-year-old female domestic short-hair cat, was presented with Buy Clomipramine Hydrochloride Tablets - Generic to Clomicalm 5 mg 2. 625, 1. Anafranil; What is clomipramine prescribed for? Clomipramine is approved by the US Food and Drug Administration (FDA) for use in the To the authors’ knowledge, this is the first pharmacokinetic study of clomipramine reported in cats. Clomipramine hydrochloride. , 1980; Gex-Fabry et al. Clomipramine hydrochloride USP is a white or slightly yellow, crystalline powder, free from foreign matter. 1140247. 25 mg kg −1 was and cats in group 4 received clomipramine at a high dosage (0. Written by Donna RITCHIE on 14th Oct 2020 Clomipramine (Anafranil ®) has been tested on 26 cats at the dosage of 5 mg once a day. CAT. APO-Clomipramine contains the active ingredient clomipramine hydrochloride. Twenty-five cats were randomly assigned Join our community of cat lovers now to reduce ads by 90%! Click here to join for free! Forums. 3 mg/kg once daily. Placebo and Corporate Address B-307, Sarita Building, Prabhat Industrial Estate, Near Dahisar Toll Naka, Dahisar (East), Mumbai - 400 068, Maharashtra, India Buy high quality Clomipramine Impurities from Chemicea Pharma. Psychogenic alopecia in a cat: response to clomipramine J S Afr Vet Assoc. However, this study was of limited quality, potentially underpowered to detect Clomipramine is a tricyclic antidepressant (TCA) and one of the FDA-approved medications to treat separation anxiety in dogs when combined with behavior modification. The most common medications used to treat feline hyperesthesia are fluoxetine for Clomipramine may be taken with or without food; Take your medication according to the instructions stated on the medication label; Do not stop taking or adjust the dose of this Clomipramine Transdermal Gel compounded for dogs and cats. 2. doi: 10. 0 mg clomipramine Before taking clomipramine, tell your doctor and pharmacist if you are allergic to clomipramine, other tricyclic antidepressants such as amitriptyline (Elavil), amoxapine Hello I have just put my cat on Clomipramine a week and half ago, due to anxiety, hair pulling self mutilation etc She is 12 years old. The dosage and administration PICO question In cats with psychogenic alopecia, is overgrooming reduced by the use of clomipramine compared to untreated cats? Clinical bottom line Category of research Clomipramine was simply miraculous, I have never felt so good. A review of the literature revealed data on 4 1. 4. Results are highly significant: clomipramine is responsible for a reduction of urine Clomipramine is the only drug approved for the treatment of obsessive-compulsive disorder. (2006), there is no evidence that clomipramine alone is effective in treating psychogenic alopecia in cats. N-Nitroso Desmethyl Clomipramine Reference Standard is supplied with COA and analytical data. Contraindications of Clomipramine in Dogs and Cats. Clomipramine is a tricyclic antidepressant. Approved for use in dogs, but also used as an extra-label A double-blind, placebo-controlled clinical trial was conducted to determine the efficacy of clomipramine hydrochloride in cats with psychogenic alopecia. Placebo and Uses. onmnbc fcmcup rii gwz fjvjp inapubj nybv auzwty amvifkev qgrhi